Ursodeoxycholic acid

Ursodeoxycholic acid

Ursodeoxycholic acid is a medication used in the management and treatment of cholestatic liver disease. It is another derivative of cholic acid that is used in treatment of various gastric aliments in patients.
The use of ursodeoxycholic acid (UDCA), also known as ursodiol, in treating liver disease dates back more than a hundred years when it was first employed in traditional Chinese medicine by herbalists and physicians alike. Before discovering its effectiveness in dissolving gallstones, its primary use was as a liver tonic. Today, there is extensive evidence suggesting that UDCA is beneficial in various types of liver pathology. However, the greatest amount of data still points to its therapeutic effect in treating gallstone disease. It has a melting point of 203 ºC and solubility in water Is at 20mg/L.
Gallstone disease is a common and exceedingly costly digestive disorder if considering the number of hospital admissions and cholecystectomies performed in the United States annually. It is a complex disorder where both genetic and environmental factors contribute to the susceptibility of the disease. The primary non-invasive treatment for cholesterol gallstones is oral litholysis with bile acids. UDCA has been shown to decrease the biliary cholesterol saturation markedly and has found use as an alternative to cholecystectomy in patients with gallstone disease. Biliary sludge is considered to be another therapeutic target of UDCA therapy. It’s an occurrence commonly precipitated by rapid weight loss, pregnancy, and total parenteral nutrition. A clinical study in which patients with idiopathic acute pancreatitis attributed to microscopic gallstones or biliary sludge showed complete resolution of gallbladder microlithiasis after UDCA treatment, demonstrating its therapeutic effect.
UDCA is commonly used to treat patients with primary biliary cholangitis (formerly known as primary biliary cirrhosis), an immune-mediated cholestatic liver disease characterized by the destruction of intrahepatic bile ducts. UDCA is the only drug approved by the U.S Food and Drug Administration to treat primary biliary cholangitis. Studies suggest that UDCA can significantly delay the progression of liver cirrhosis in patients with early stages of PBC. In one study, the probability of remaining free of extensive fibrosis or cirrhosis after UDCA treatment was 76% and 61% after being treated for 4 and 8 years, respectively. Similar results have been observed in other case-control studies as well.

Ursodeoxycholic acid from Bacto Chem

Bacto Chem’s Ursodeoxycholic acid is manufactured domestically in India Using Indian bovine-source Bile, which is used to manufacture cholic acid, the key starting material in the manufacturing process of UDCA. Our patented manufacturing process gives us an edge over our competitors owing to our process’ superiority in terms of yield and quality.
Indian cattle are often recognised and believed to be better for human consumption because:
Absence of Bovine Spongiform Encephalopathy (BSE), or Mad Cow Disease
• BSE is caused in cattle when the animals are fed with meat or bone meal. Protein cells become twisted into prions. Prions are NOT DESTROYED by fire, freezing, disinfectants, sterilization procedures or radiation.
• Indian cattle are grass fed, this factor removes the possibility of these cattle encountering BSE,
• Cholic Acid prepared from Indian cattle is free of BSE/TSE.
Greater bioavailability:
• Bovine sourced proteins and APIs show greater affinity of binding with human cells to show greater affinity of binding, showing greater efficacy.

All Bacto Chem Products are manufactured in compliance with the World Health Organization (WHO) Current Good Manufacturing Practices (cGMP) under strict conditions in state-of-the-art facilities. This results in products that are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the product specification. Each of our products is manufactured in a dedicated block with no cross-contamination.
Our strengths lie in our highly trained and experienced QC department which ensures all the raw materials go through stringent testing prior to their utilisation, ensuring that only raw materials of the highest quality are used only after approval from QC. We ensure that all our equipment and manufacturing process are thoroughly validated and updated. We invest heavily on training our production and QC teams to understand and monitor every stage of the production cycle to ensure safety and highest quality product. Maintaining cleanliness is our responsibility, and we always focus on ensuring proper measures are taken to follow our validates cleaning protocols to avoid batch to batch contamination. Additionally, Bacto Chem is compliant with the requirements of OHSAS 18001:2007 in occupational health and safety management systems. Bacto Chem is also ISO 14001:2015 certified which recognizes us as an organization seeking to manage its environmental responsibilities in a systematic manner that contributes to the environmental pillar of sustainability and has the necessary Halal certifications as well.

All Bacto Chem Products are manufactured in compliance with the World Health Organization (WHO) Current Good Manufacturing Practices (cGMP) under strict conditions in state-of-the-art facilities. This results in products that are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the product specification. Each of our products is manufactured in a dedicated block with no cross-contamination.
Our strengths lie in our highly trained and experienced QC department which ensures all the raw materials go through stringent testing prior to their utilisation, ensuring that only raw materials of the highest quality are used only after approval from QC. We ensure that all our equipment and manufacturing process are thoroughly validated and updated. We invest heavily on training our production and QC teams to understand and monitor every stage of the production cycle to ensure safety and highest quality product. Maintaining cleanliness is our responsibility, and we always focus on ensuring proper measures are taken to follow our validates cleaning protocols to avoid batch to batch contamination.
Additionally, Bacto Chem is compliant with the requirements of OHSAS 18001:2007 in occupational health and safety management systems. Bacto Chem is also ISO 14001:2015 certified which recognizes us as an organization seeking to manage its environmental responsibilities in a systematic manner that contributes to the environmental pillar of sustainability and has the necessary Halal certifications as well.